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A signaling pathway in melanoma cells is affected by erectile dysfunction drug Sildenafil, biochemists have discovered. Sildenafil is used to treat erectile dysfunction and is the active ingredient in a number of drugs which have been on the market since the late 1990s. Sildenafil is now also…
http://dlvr.it/KlJsPb

The activity level -- expression -- of the SMARCA4/BRG1 gene in lung tumors might identify lung-cancer patients who will likely be helped by a particular chemotherapy regimen given to prevent tumor recurrence after surgery, report researchers.
http://dlvr.it/KlJsPY

The chances of incarceration in America are always higher for blacks than for whites or Hispanics, regardless of their level of wealth, according to a new study. In addition, blacks and Hispanics who had previously served jail time were significantly poorer than their white counterparts.
http://dlvr.it/KlJsPX

Gut microbes alter platelet function and risk of blood clot-related illnesses like heart attack and stroke, researchers have demonstrated -- for the first time -- through a combination of both clinical studies of over 4,000 patients and animal model studies.
http://dlvr.it/KlJsPT

Insufficient sleep can decrease a commercial motor vehicle driver's level of alertness, which may increase the risk of a crash, yet little is known about effective ways to minimize that risk, says a new report.
http://dlvr.it/KlJsPC

Rustling leaves, a creaking branch: To a mouse, these sensory impressions may at first seem harmless -- but not if a cat suddenly bursts out of the bush. If so, they were clues of impending life-threatening danger. Scientists have now found how the brain can link sensory perceptions to events…
http://dlvr.it/KlJsM3

Combining the two most powerful biological tools of the 21st century, scientists have modified how the genome of induced pluripotent stem cells (iPSCs) is read for the first time using a variation of the CRISPR-Cas9 system. The development offers a major technological advance in creating cell…
http://dlvr.it/KlJs52

Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs lapatinib and trastuzumab before surgery and chemotherapy, saw their tumors shrink significantly or even disappear, according to results from a clinical trial.
http://dlvr.it/KlJLpc

Brown fat is well known for protecting the body from cold temperatures, and now researchers have discovered that this cell type in humans shows circadian rhythms in its consumption of glucose -- an energy fuel for heat production. These rhythms, which rise just before waking, may have evolved as a…
http://dlvr.it/KlJLhk

The best way to keep consumers happy and interested with initial sequel movies or products is to balance familiarity, innovation and nostalgia and make small "iterated offerings," instead of sweeping changes. The deeper into a franchise or product line, the more changes are accepted and expected, a…
http://dlvr.it/KlGx2w

Fragile skin that blisters easily: 90 percent of the patients that suffer from the skin condition recessive dystrophic epidermolysis bullosa (RDEB) develop rapidly progressing cutaneous squamous cell carcinomas, a type of skin cancer, by the age of 55. 80 percent of these patients will die due to…
http://dlvr.it/KlGwr5

This is the first time a randomized, double-blind, clinical trial has shown that a nutritional intervention can help to conserve the ability of prodromal AD patients to carry out everyday tasks, such as paying bills, or finding your way around, as measured by the Clinical Dementia Rating-Sum of…
http://dlvr.it/KlGwYr

A new pilot study is underway into bus drivers' sedentary behavior (prolonged sitting) during and outside working hours. Bus drivers are typically sitting for more than 12 hours a day due to the demands of the job -- three hours longer than office workers.
http://dlvr.it/KlGhkd

New scanning technology which will give a much clearer picture of lung disease, say researchers, who report that the technology has taken a major step forward.
http://dlvr.it/KlGhkW

Every day, thousands of sports organisations, associations, clubs and competition organisers have to schedule fixtures for leagues and tournaments all over the world. Who is playing who, and when? A Norwegian company is aiming to become a world leader in fixture scheduling for handball, football…
http://dlvr.it/KlGhkR

Researchers have optimized the techniques for studying motor learning in order to repeatedly assess the activity of neurons for days, weeks, or even months. These sophisticated approaches allow the further characterization of the neurons that are continuously engaged during motor activity and…
http://dlvr.it/KlGhkC

Changes in income do not affect most people's happiness, most of the time, according to a new study.
http://dlvr.it/KlGhj4

People with leukemia could be helped by new research that sheds light on how the body produces its blood supply. Enabling scientists to grow the stem cells artificially from pluripotent stem cells could also lead to the development of personalized blood therapies, researchers say.
http://dlvr.it/KlGhdG

Male breast cancer (Male BC) has important biological differences that distinguish it from female breast cancer, but to date these have been little studied and Male BC patients have been excluded from many clinical trials in breast cancer. Male patients are also usually diagnosed later when their…
http://dlvr.it/KlGhPg

Hispanic women who identify as Black or another race have worse functional health than their counterparts who identify as White, according to new research.
http://dlvr.it/KlGgC2

New research that sheds unprecedented light on the behavior of blasts produced by landmines and Improvised Explosive Devices (IEDs) could aid the development of enhanced protection for UK soldiers on military, peace-keeping and humanitarian missions.
http://dlvr.it/KlGfxQ

'Ultra-processed' foods make up more than half of all calories consumed in the US diet, and contribute nearly 90 percent of all added sugar intake, finds new research.
http://dlvr.it/KlFzGw

Some patients with breast cancer, lung cancer and leukemia seem to fare poorly after treatment because of the effects of a particular gene, a new study finds. The gene, called CYP3A7, is normally only active in infancy, but in some people it continues to be switched on into adulthood, and…
http://dlvr.it/KlD345

Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations, say researchers, noting that the drug D-cycloserine may help here.
http://dlvr.it/KlD2t4

Your personal risk of developing complex diseases such as diabetes, depression or cancer is influenced in part by genetic variants, that is, letters in your DNA sequence that differ between people. These variants disrupt networks of interacting genes in different tissues of your body, two studies…
http://dlvr.it/KlD2fY

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