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A new drug that harnesses the immune system to attack tumors is highly effective against advanced bladder cancer, according to the results of an international clinical trial.

The experimental "smart-bomb" drug rovalpituzumab tesirine (Rova-T) appears safe and shows efficacy in treating patients with advanced small cell lung cancer, according to results from a first-in-human clinical trial.

The immune checkpoint blockade drug nivolumab reduced tumor burden in 24.4 percent of patients with metastatic bladder cancer, regardless of whether their tumors had a biomarker related to the drug's target, according to clinical trial results.

The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation.

A study of 4,699 tumor samples finds Wnt pathway genes CTNNB1 and FAM123B specifically upregulated in colorectal cancer of patients under age 50.

Lenalidomide maintenance following stem cell transplant now a standard of care for people with multiple myeloma

Having radiotherapy once a day for six and a half weeks or twice a day for three weeks -- when combined with chemotherapy -- is equally good at treating small cell lung cancer that hasn't spread.

Costs associated with different breast cancer chemotherapy regimens can vary significantly, regardless of effectiveness, according to new research.

Hispanic white and non-Hispanic black cancer patients between ages 15 and 29 may be more likely than same-aged white patients to die of their disease, according to a new study. The finding is partially but not wholly explained by socioeconomic status, meaning that in addition to the health risks…

A significant proportion of lung cancer patients also have autoimmune disease, which may make them unsuitable for increasingly popular immunotherapy treatments, a team of researchers has found.

Researchers have found that adding increasing doses of an approved Type 2 diabetes drug, metformin, to a chemotherapy and radiation treatment regimen in head and neck cancer patients is not well tolerated if escalated too quickly, but allowing slower escalation could be beneficial.

As living donors become an increasingly important source of organs for kidney and liver transplantation, the world transplant community strives to ensure that these life-saving procedures maximize the benefits to recipients while minimizing the risks to donors. A thorough update on living-donor…

Cancer and Alzheimer's disease drugs target specific proteins, blocking or inhibiting their natural interactions, which may be in overdrive. The traditional drug design process typically assumes the protein shapes are static. But tradition turns out to be too limiting, according to new research.

The Micra® Transcatheter Pacing System (TPS) -- the world's smallest pacemaker -- has now been gained U.S. Food and Drug Administration (FDA) approval.

Vaccines are usually medicine's best defense against the world's deadliest microbes. However, HIV is so mutable that it has so far effectively evaded both the human immune system and scientists' attempts to make an effective vaccine to protect against it. Now, researchers have figured out how to…

The mosquito-borne Zika virus linked to microcephaly and other neurological problems in newborns of affected mothers directly infects the brain progenitor cells destined to become neurons, researchers report in a new study.

While we may think some people are consistently wise, we actually demonstrate different levels of wisdom from one situation to the next, and factors such as whether we are alone or with friends can affect it, according to new research.

Large, highly concentrated populations of crows can easily spread disease -- not only among their own species, but quite possibly to humans, either via livestock, or directly. During winter, approximately half of the 6,000 American crows that congregated at the study site carried Campylobacter…

The authors of a new article discuss the growing tension between an arguably necessary role urban areas play in society and the numbing, even debilitating, aspects of cities that disconnect humans from the natural world.

Eight weeks after receiving their first samples of Zika virus, scientists have shown that a very small protein we all have in our bodies, interferon-induced protein 3 (IFITM3), can dramatically reduce the ability of Zika virus to infect human and mouse cells.

Dopamine signaling within the cerebral cortex can predict changes in the extent of communication between key brain networks during working memory, report scientists.

A person's genetic makeup plays a role in autoimmune diseases that develop when the body is attacked by its own immune system. But little is known about how immune cells are pushed into overdrive. Now, in new research that points to potential therapeutic targets for autoimmune diseases, researchers…

Researchers will present results of the phase 3 NETTER-1 study, showing clinically meaningful and significant results for Lutathera (77Lu-DOTA0-Tyr3-Octreotate) in patients with metastatic midgut neuroendocrine tumors (NETs).

Delivering genetic test results to patients at risk for cancer-causing genetic mutations over the phone helps to ease cost and transportation burdens and, compared to receiving results in person, does not cause patients additional stress, according to a new study.

They're inside our gut, on the skin, and in the mouth. Thousands of different types of micro-organisms live in and on the body, playing helpful roles in digestion or in aiding the body's natural defense system. Now, scientists have found tiny organisms living in the upper female reproductive tract,…

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