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An existing medication could have promise in preventing breast cancer in women carrying a faulty BRCA1 gene, researchers have discovered.
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Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases. Researchers have taken that critical first step by providing a crystal structure of the extracellular domain, or ECD, of ZIP4 -- the exclusive protein responsible for the…
http://dlvr.it/LcGXKq

Scientists have synthesized a novel anti-cancer agent, Thailanstatin A, which was originally isolated from a bacterial species collected in Thailand.
http://dlvr.it/LcGXHh

The US clothing industry is a multi-billion dollar industry, but for the millions of Americans with disabilities and their families, a lack of options in the apparel industry presents daily challenges. One researcher has found that the lack of adequate, accessible apparel created barriers for…
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Due to a subgroup effect, reviewers have found that there is an indication of a minor added benefit for patients with diabetes, and an indication of a considerable added benefit for patients without diabetes, when using Sacubitril/valsartan in heart failure.
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A new 'brute force' technique has been developed to test thousands of biochemical reactions at once and quickly home in on the range of conditions where they work best. Until now, optimizing such biomolecular systems, which can be applied for example to diagnostics, would have required months or…
http://dlvr.it/LcFbBf

A team has been able to understand and manipulate DNA to more finely tune the flow of electricity through it. The key findings, which can make DNA behave in different ways -- cajoling electrons to smoothly flow like electricity through a metal wire, or hopping electrons about like the…
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A study of patients in a Minnesota county suggests the incidence (new cases) of parkinsonism and Parkinson's disease may have increased over the past 30 years but that trend may not be genuine and must be confirmed in other populations.
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Scientists have identified four new risk genes that are altered in patients with multiple sclerosis. The results point to a possible involvement of cellular mechanisms in the development of the disease, through which environmental influences affect gene regulation.
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A receptor, first known for its role in mediating the harmful effects of the environmental pollutant dioxin in our body, is now understood to play other important roles in modulating the innate immune response.
http://dlvr.it/LcDmPm

Using tiny, alpaca-derived, single-domain antibody fragments, scientists have developed a method to perturb cellular processes in mammalian cells, allowing them to tease apart the roles that individual proteins play in these pathways. With improved knowledge of protein activity, scientists can…
http://dlvr.it/LcDSy2

Three to 5 percent of the European population is allergic to insect venom, and many of them are at risk of anaphylaxis if they are stung. Some patients do not respond properly to immunotherapy and in some cases the treatment has reduced or no effect at all -- which can be fatal. Researchers are now…
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Due to a lack of studies of direct comparisons the manufacturer subsequently submitted historical comparisons, but the visible effects were not large enough for conclusions on added benefit.
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Rising blood levels of a protein called hematoma derived growth factor (HDGF) are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs, report researchers.
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In a surprising twist, benign brain tumors that have previously been tied to obesity and diabetes are less likely to emerge in those with high blood sugar, new research has found.
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Researchers have identified a new genetic candidate for testing therapies that might affect fear learning in people with PTSD or other conditions, describes a new report.
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In the fight to end opioid abuse, Blue Cross Blue Shield in at least two states is denying coverage of a proven nonopioid treatment for chronic pain, a new article outlines.
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If you are a male immigrant and marry a woman from a country other than your own, you increase your chances of a good job and a high income. This applies whether the woman you marry is a native or not.
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New research suggests that microbial water quality issues of Flint drinking water are improving, based on recent testing in March 2016, but that continued vigilance is in order. The research found that levels of DNA markers for Legionella have decreased throughout Flint since October 2015 before…
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Measuring antibody levels in the blood could be used to detect a person's heart attack risk after researchers discovered that higher levels of these antibodies are linked to a lower heart attack risk.
http://dlvr.it/LcCZWN

New research provides compelling evidence that children acquire Streptococcus mutans, the bacterium most frequently associated with dental caries, from intra- and extra-familial sources besides their mother.
http://dlvr.it/LcCGMB

New research provides clear evidence that the gloves of healthcare workers contaminate hospital surfaces with bacteria. The researchers' data also suggest that types of bacteria may affect cross-transmission rates among contaminated gloves and the hospital surfaces.
http://dlvr.it/LcCGCC

Research demonstrates a new way bacteria can cause dramatic morphological changes in human cells. Specifically, the researchers discovered that a common bacterial contaminant of contact lenses and cases can cause the formation of large bubble-like membrane structures on human ocular cells, which…
http://dlvr.it/LcCG0L

Cannabis use during pregnancy is associated with abnormal brain structure in children, according to a new study. Compared with unexposed children, those who were prenatally exposed to cannabis had a thicker prefrontal cortex, a region of the brain involved in complex cognition, decision-making, and…
http://dlvr.it/LcBxvj

Pathologists have been largely diagnosing disease the same way for the past 100 years, by manually reviewing images under a microscope. But new work suggests that computers can help doctors improve accuracy and significantly change the way cancer and other diseases are diagnosed.
http://dlvr.it/LcBxgL

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