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CRISPR-Cas9 is a powerful tool to edit genomes, but off-target edits are a concern. Now studies detail three checks the Cas9 protein makes to ensure it binds the right DNA and that the sequence matches the RNA primer sufficiently to warrant cutting. At most off-target sites, Cas9 binds for…

Small steps can equal big changes when it comes to diabetes. A doctor explains how to lower your risk for diabetes and pre-diabetes.

An unexpected effect from a gene known to increase diabetes risk has been identified by researchers. They assumed that the specific allele in the gene TCF7L2 which increases the risk of type 2 diabetes, impairs insulin production in response to increased insulin resistance. Some slight evidence of…

When people are listening to music, their emotional reactions to the music are reflected in changes in their pupil size. Researchers now show for the first time that both the emotional content of the music and the listeners' personal involvement with music influence pupil dilation. This study…

A new study of mouse cells has revealed reasons why attempts to grow stem cells to maturity in the laboratory often fail, and provided a possible way to overcome such 'developmental arrest.'

Disparities in colorectal cancer death rates take a large toll on the national economy, with poorer, less-educated communities bearing the greatest burden, according to new data.

The likelihood of receiving curative-intent surgery for patients with early-stage non-small cell lung cancer varies substantially from state to state, according to new data.

A healthy diet may reduce the risk of ovarian cancer in African-American women, according to new data.

The first breast cancer risk-prediction model based entirely on data from Hispanic women, including whether a woman was born in or outside of the United States, provided a more accurate assessment of Hispanic women's risk of developing breast cancer compared with existing models based on data from…

Based on the results of EORTC trial 18071, the FDA expanded the approval of Yervoy (ipilimumab) in melanoma to include adjuvant treatment of patients with stage 3 melanoma at high risk of recurrence following complete resection.

The relationship quality of 721 couples in Switzerland over a period of thirteen years is at the core of new research. A researcher demonstrated that while the various styles of conjugal interactions generally remain stable along the life course, some critical life events and transitions weigh much…

Programmable digital glasses for lazy eye work as well as eye patching, study shows, improving vision by about 2 lines on the reading chart after 3 months. First new effective lazy eye treatment in 50 years.

Mass prostate cancer (PSA) screening before the age of 55 may not have any benefit over screening starting after the age of 55, according to a new 20 year analysis of 6822 patients.

Fighting and assault caused nearly 8,000 eye injuries treated in hospitals from 2002-2011, while falling led causes of ocular trauma with more than 8,500 incidents reported.

An integrated approach to providing access to reliable and safe transportation is needed for adults on the autism spectrum and their families, according to a new study that offers recommendations for removing barriers to better mobility.

Tasting food relies on food volatiles moving from the back of the mouth to the nasal cavity, but researchers have wondered why airflow doesn't carry them in the other direction, into the lungs. Now a team of engineers, using a 3-D printed model of the human airway from nostril to trachea, has…

What can you tell about people and their situations from only 140 characters? Quite a lot according to a new study about Twitter. To date, no research has tapped the vast data from social media to study situations. Using more than 20 million tweets, researchers provide insights about the…

Scientists have uncovered the role of cyclin -- the protein molecule that drives the growth of malaria within mosquitoes. The research could pave the way to better understanding of how the malaria parasite thrives and lead to potential new treatments.

Approximately 12 million people in the United States experience diagnostic errors annually, but it is time for a change, according to experts, who say that by reducing misdiagnosis, patient safety is measurably improved.

Among patients with proliferative diabetic retinopathy, treatment with an injection in the eye of the drug ranibizumab resulted in visual acuity that was not worse than panretinal photocoagulation at two years, according to a study.

A cost-effective one-step test that screens, detects and confirms hepatitis C virus (HCV) infections has been developed by researchers. Current blood-based HCV testing requires two steps and can be expensive, inconvenient and is not widely available or affordable globally.

A significant discovery has been made that might lead to the delay or prevention of the most common cause of blindness in the elderly: age-related macular degeneration (AMD). Patients who take the drug L-DOPA (for Parkinson Disease, Restless Legs or other movement disorders) are significantly less…

An increasing amount of drugs taken by humans and animals make it into streams and waterways, and pharmaceutical pollution has had catastrophic ecosystem consequences despite low levels of concentration in the environment. The effect of pharmaceuticals and other contaminants of emerging concern on…

Intake of gluten up until two years of age increases risk of celiac disease at least two-fold in children with genetic risk factors for this disease, according a new study.

Unequal growth between genetically identical monozygotic twins in the womb may be triggered in the earliest stages of human embryo development, according to a new study.

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