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Biochemists have long known that crucial cell processes depend on a highly regulated cleanup system known as proteolysis, where specialized proteins called proteases degrade damaged or no-longer-needed proteins. They must destroy specific targets without damaging other proteins, but how this…
http://dlvr.it/CQ9k3Q

Using a genome-wide association study, scientists have identified subtle genetic changes that can cause substantial differences to how we fight viral infections. The new work connects genetics to antiviral immunity while offering a new path for studying this relationship in other medical contexts.
http://dlvr.it/CQ9r24

A new explanation has been found for how aspirin works in the body to reduce the risk of heart disease and certain cancers. Aspirin's active form, salicylic acid, blocks a protein called HMGB1, which triggers inflammation in damaged tissues. The new findings may explain the disease-preventing…
http://dlvr.it/CQ9RSk

A single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis, new research shows. This is the first demonstration that introduction of blood in the healthy brain is sufficient to cause peripheral immune cells to enter the brain, which then go on to…
http://dlvr.it/CQ9Rhy

The first three-dimensional image of a key protein known to be involved in the development of blood and other cancers has been created by scientists. This discovery showed the protein, called Trib1, plays a vital role in controlling how and when other proteins are degraded, which is essential for…
http://dlvr.it/CQ9VMD

Most teens in grades 7-12 would prefer to know the results of unanticipated findings found in whole exome sequencing genetic testing, even if the findings are not medically actionable until adulthood, according to survey data. The survey addressed secondary findings gleaned from sequencing the…
http://dlvr.it/CQ9Ts8

A mysterious kidney disease that has killed over 20,000 people in Central America, most of them sugar cane workers, may be caused by chronic, severe dehydration linked to global climate change, according to a new study.
http://dlvr.it/CQ9Rh7

After viewing CT scan results, physicians in the emergency departments of four major academic medical centers made key changes in clinical decision-making for patients with symptoms frequently seen in emergency rooms, a new report suggests.
http://dlvr.it/CQ9Qwz

A team of Ludwig Cancer Research scientists has mapped out how a mutant version of the epidermal growth factor receptor (EGFR) known as EGFRvIII specifically drives critical processes that alter the reading of the genome to fuel the growth of the brain cancer glioblastoma multiforme and -- most…
http://dlvr.it/CQ9Wkh

Our cells contain proteins, essential to functions like protein creation and DNA repair but also involved in forms of ALS and cancer, that never take a characteristic shape, a new study shows. Instead it's how they become huddled with each other into droplets that matters. Scientists may therefore…
http://dlvr.it/CQ97GG

A common cause of bone loss is an overactive parathyroid gland, which doctors usually treat with surgery. New research on how excess parathyroid hormone affects immune cells suggests that doctors could repurpose existing drugs to treat hyperparathyroidism without surgery.
http://dlvr.it/CQ96NR

Intracellular receptor signalling sustains cancer cells that have detached from the surrounding tissue, new research shows. When the signalling is prevented, the cells cannot spread to other parts of the body. This significant research result influences how cancer research is directed in the future.
http://dlvr.it/CQ93gm

Despite manufacturing and legislative changes to improve workplace hygiene, the risk of occupational bladder cancer appears to be on the rise in some industries, although the profile of at-risk occupations has changed over time, according to a new article.
http://dlvr.it/CPqp12

First-born individuals in a sample of adults in the United Kingdom were more likely to be nearsighted than later-born individuals in a family, and the association was larger before adjusting for educational exposure, suggesting that reduced parental investment in the education of children with…
http://dlvr.it/CPqlCs

Results from a new survey finds that only half of healthcare professionals consider themselves to be adequately equipped with information about cryptogenic stroke, a stroke in which the underlying cause is still unknown after extensive testing. Depending on their specialty, 51-70 percent of…
http://dlvr.it/CPqVHp

Surgical removal of melanoma that has metastasized, or spread, to the abdomen appears to help patients live more than twice as long as those who receive only medical therapy, according to study results.
http://dlvr.it/CPqG62

Helmeted bicycle riders have a 58 percent reduced odds of severe traumatic brain injury after an accident compared to their non-helmeted counterparts, according to researchers.
http://dlvr.it/CPqHC7

As time lapses, many colonoscopy patients become less and less likely to recall when and where they last had the procedure performed; who the doctor was who performed it; whether polyps were found, and, if so, the number and size of those polyps, according to new study results.
http://dlvr.it/CPqFh3

The 2015 Nobel Prize in Physiology or Medicine has been jointly awarded for research involving natural products.
http://dlvr.it/CPM1LD

It was hoped that the development of accelerated partial breast irradiation would increase the number of early-stage breast cancer patients getting radiation treatment. A new study, however, has found that adoption of the technique has stagnated -- and many women still aren't getting the radiation…
http://dlvr.it/CPHljb

Presenting and discussing a menu of treatment options is good for both the patient and the physician according to a new article.
http://dlvr.it/CPHg8V

A new study finds tobacco users would pay more for a health insurance plan from the Affordable Care Act exchanges than non-tobacco users in nearly every county of the 37 states that used healthcare.gov to sell their plans in 2015.
http://dlvr.it/CPHcdz

Treatment patterns for ductal carcinoma in situ (DCIS) have shifted since the 1990s, with more U.S. women opting for lumpectomy in combination with radiation rather than single-breast mastectomy, according to a study. But the researchers also found an increased tendency for women to seek removal of…
http://dlvr.it/CPH2Nf

While resident physicians responsible for the care of hospital patients are always able to call a supervising senior physician for advice on handling situations that may come up, which situations require immediate consultation and which can wait until the next day can sometimes be unclear. A new…
http://dlvr.it/CPGzfy

A new study shows that Magnet hospitals nationally accredited for nursing excellence have higher patient ratings of care than other hospitals. The study suggests that hospitals seeking to improve patient satisfaction, and qualify for new financial incentives, would be well advised to consider…
http://dlvr.it/CPGysp

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